Phenotype Image Detail

Image

Caption

Craniofacial defects in Wfikkn2^tm1.1Sjl/Wfikkn2^tm1.1Sjl Gdf11^tm1Sjl/Gdf11^tm1Sjl (Gasp1^-/-;Gdf11^-/-) mice. (A-D) Ventral views of the newborn mouse skull. The boxed regions in A and B are shown at higher magnification in C and D. Palatine (p) bones (arrow) are missing, and the distance between the pterygoid (pt) processes (arrowheads) is widened in the Gasp1^-/-;Gdf11^-/- skull. (E and F) Coronal sections of the mouse head at E18.5. The palatal shelves fail to fuse in the mutant embryos.

Copyright

This image is from Lee YS, Proc Natl Acad Sci U S A 2013 Sep 24;110(39):E3713-22. Copyright 2013 National Academy of Sciences, U.S.A. J:201148

Associated Alleles

Symbol	Name
Gdf11^tm1Sjl	growth differentiation factor 11; targeted mutation 1, Sejin Lee
Wfikkn2^tm1.1Sjl	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2; targeted mutation 1.1, Sejin Lee

Associated Genotypes

Allelic Composition	Genetic Background
Gdf11^tm1Sjl/Gdf11^tm1Sjl Wfikkn2^tm1.1Sjl/Wfikkn2^tm1.1Sjl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6