Phenotype Image Detail

Image

Caption

Sizes and histological analyses of hearts of Apoe^tm1Unc/Apoe^tm1Unc Scarb1^tm1Kri/Scarb1^tm1Kri mice. (A). Survival curve. Arrows indicate ages at which hearts were harvested. (B) Heart (mg) to body weight (g) ratio at 21, 31, and 43 d (n = 10, 10 and 12, respectively) (C-H) Low and high magnification images of Movat pentachrome-stained transverse sections of ventricles. Histological analysis of hearts in surviving mice showed that at 21 days there was no apparent coronary arterial lesions or myocardial infarctions (MIs; C and D), whereas at 31 days there were atherosclerotic coronary arterial occlusions and small MIs (E and F, modest disease), and at 43 days there were coronary arterial occlusions and extensive MI (G and H, severe disease). (Scale bar in C, E, and G: 1 mm; and in D, F, and H: 100 um.) Boxes in C, E, and G indicate the locations of the high magnification images. The black and white stars indicate the left and right ventricles. The arrows and arrowheads indicate microscopic scarring.

Copyright

This image is from Tsukamoto K, Proc Natl Acad Sci U S A 2013 Oct 15;110(42):17023-8. Copyright 2013 National Academy of Sciences, U.S.A. J:201999

Associated Alleles

Symbol	Name
Apoe^tm1Unc	apolipoprotein E; targeted mutation 1, University of North Carolina
Scarb1^tm1Kri	scavenger receptor class B, member 1; targeted mutation 1, Monty Krieger

Associated Genotypes

Allelic Composition	Genetic Background
Apoe^tm1Unc/Apoe^tm1Unc Scarb1^tm1Kri/Scarb1^tm1Kri	involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6