Phenotype Image Detail

Image

Caption

The effects of null mutations of Apod on plasma Apod (D) and infarct size after in vivo myocardial I/R injury of wild-type mice (E, and F). Male mice were subjected to myocardial ischemia (45 min in E and F)/reperfusion (24 h). Fluorescent microspheres were used to visualize the area at risk (AAR). (D-F) WT (n = 7, Left) or Apod^tm1Bres/Apod^tm1Bres (ApoD KO) (n = 10, Right) mice (11 wk old) were examined. (D) SDS/PAGE/immunoblotting analysis of plasma apoD (30 ug of protein per lane). (E) Representative images of 2,3,5-triphenyl tetrazolium chloride (TTC)-stained sections of hearts. Infarct areas (white) are indicated with arrow heads. (F) Relative infarct sizes (infarct area/AAR) (##P < 0.005, **P < 0.0001).

Copyright

This image is from Tsukamoto K, Proc Natl Acad Sci U S A 2013 Oct 15;110(42):17023-8. Copyright 2013 National Academy of Sciences, U.S.A. J:201999

Associated Alleles

Symbol	Name
Apod^tm1Bres	apolipoprotein D; targeted mutation 1, Jan L Breslow

Associated Genotypes

Allelic Composition	Genetic Background
Apod^tm1Bres/Apod^tm1Bres	B6.129-Apod^tm1Bres