Phenotype Image Detail

Image

Caption

Genetic interaction analysis of Hivep3 (Shn3) with Atf4 in bone. Radiographic (A) and histomorphometric (B,C) analysis of the tibia of 10 week old in wild-type (WT), Atf4^tm1TowAtf4^tm1Tow (Atf4^-/-), Hivep3^tm1GlmHivep3^tm1Glm (Shn3^-/-) and Atf4^tm1Tow/Atf4^tm1Tow Hivep3^tm1Glm/Hivep3^tm1Glm (Atf4^-/-;Shn3^-/-) mice. Values are mean + SD. "*" indicates a significant difference by the Student's t-test, t < 0.05.

Copyright

This image is from Shim JH, J Clin Invest 2013 Sep 3;123(9):4010-22 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:201597

Associated Alleles

Symbol	Name
Atf4^tm1Tow	activating transcription factor 4; targeted mutation 1, Timothy Townes
Hivep3^tm1Glm	human immunodeficiency virus type I enhancer binding protein 3; targeted mutation 1, Laurie H Glimcher

Associated Genotypes

Allelic Composition	Genetic Background
Hivep3^tm1Glm/Hivep3^tm1Glm	involves: C57BL/6
Atf4^tm1Tow/Atf4^tm1Tow Hivep3^tm1Glm/Hivep3^tm1Glm	involves: 129 * C57BL/6