Phenotype Image Detail

Image

Caption

Knock-out (KO) mice have decreased intestinal smooth muscle cell proliferation. A, Ki67 (red) and smooth muscle-alpha-actin (green) staining of cross-sections of the lower portion of small intestines from neonatal control (ctrl) and Mylk^tm1.1Bph/Mylk^tm1.1Bph/ Tg(Myh11-cre,-EGFP)2Mik/0 and mgi:5563563/mgi:5563564 mgi:2653286/0 (KO) mice. White arrows and white arrowheads point to examples of Ki67 positive smooth muscle cells in the circular and longitudinal smooth muscle layers, respectively.

Copyright

This image is from Chen M, J Biol Chem 2013 Nov 29;288(48):34647-57 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:204964

Associated Alleles

Symbol	Name
Mylk^tm1.1Bph	myosin, light polypeptide kinase; targeted mutation 1.1, B Paul Herring
Mylk^tm1.2Bph	myosin, light polypeptide kinase; targeted mutation 1.2, B Paul Herring
Tg(Myh11-cre,-EGFP)2Mik	transgene insertion 2, Michael I Kotlikoff

Associated Genotypes

Allelic Composition	Genetic Background
Mylk^tm1.1Bph/Mylk^tm1.1Bph Tg(Myh11-cre,-EGFP)2Mik/0	involves: C57BL/6 * C57BL/6N * DBA/2
Mylk^tm1.1Bph/Mylk^tm1.2Bph Tg(Myh11-cre,-EGFP)2Mik/0	involves: C57BL/6 * C57BL/6N * DBA/2