Phenotype Image Detail

Image

Caption

Morphology of the palate in wild-type (A, C, E and G) and Fras1^bfb/Fras1^bfb (B, D, F and H) mice. At E18.5 the palate has fused completely in all wild-type fetuses (A) but a proportion of mutant mice have an overt palatal cleft (B). The palatal shelves have elevated and become closely opposed in wild-type mice (C) while there is a significant delay in palatal shelf growth in mutant embryos (D). At E15.5 there is a complete fusion between the palatal shelves and nasal septum in wild-type mice (E) while a subtle palatal blister is evident in 80% of E15.5 mutant fetuses (arrowhead, F). Tgfb3 is strongly expressed in palatal shelf epithelium (arrow) of both wild-type (G) and mutants (H) but is aberrantly expressed in the nasal septum epithelium (arrowhead) in mutants. NC, nasal cavity; NS, nasal septum; VN, vomeronasal organ; T, tongue; MC, Meckel's cartilage, PS, palatal shelf.

Copyright

This image is from Miller KA, PLoS One 2013;8(10):e76342, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:208682

Associated Alleles

Symbol	Name
Fras1^bfb	Fraser extracellular matrix complex subunit 1; blood filled blisters

Associated Genotypes

Allelic Composition	Genetic Background
Fras1^bfb/Fras1^bfb	involves: C57BL/6JAnu