Phenotype Image Detail

Image

Caption

Preaxial polydactyly and blood-filled blisters in the hindlimbs of Fras1^bfb/Fras1^bfb mice. Blood-filled blisters are evident in the hindlimbs of mutants at E14.5 (A and B) and E17.5 (C and D), often distorting the digits. A proportion of mutants exhibit preaxial polydactyly (asterisks in E-H), evident in E14.5 and E17.5 wholemounts (E and F), E17.5 skeletal preparations (G) and E12.5 Sox9 in situ stained embryos (H). Evidence of a blister can also be seen in an E17.5 skeletal preparation (arrowhead in G). Digit numbers are indicated in (G).

Copyright

This image is from Miller KA, PLoS One 2013;8(10):e76342, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:208682

Associated Alleles

Symbol	Name
Fras1^bfb	Fraser extracellular matrix complex subunit 1; blood filled blisters

Associated Genotypes

Allelic Composition	Genetic Background
Fras1^bfb/Fras1^bfb	involves: C57BL/6JAnu