Phenotype Image Detail

Image

Caption

Light and electron microscopy of the adult ventricular myocardium of wild-type and Klf3^m1Cmhd/Klf3⁺ (Klf2^H275R/+) mice. In general, the structure of the mutant myocardium appeared normal when examined (A) by light microscopy, and (B) by electron microscopy. However, focal regions of contraction band necrosis (arrows) were sometimes observed in the heterozygous mutant myocardium (right) whereas this was rare in the wild type (WT) myocardium (left).

Copyright

This image is from Kelsey L, PLoS Genet 2013;9(7):e1003612, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:206507

Associated Alleles

Symbol	Name
Klf3^m1Cmhd	Kruppel-like transcription factor 3 (basic); mutation 1, Centre for Modeling Human Disease

Associated Genotypes

Allelic Composition	Genetic Background
Klf3^m1Cmhd/Klf3^+	involves: C3H/HeJ * C57BL/6J