Phenotype Image Detail

Image

Caption

Immunohistochemistry reveals that the outer hair cells of the cochlea are abnormal in Alg10b^nse5/Alg10b^nse5 mice. Cochleas were stained with phalloidin, which binds to filamentous actin (red) and anti-prestin antibody (green). In a two-month-old heterozygote (A), the expected three rows of outer hair cells are seen on the left, stained green, and the one row of inner hair cells is seen on the right, with the stereocilia clearly visible and stained red. By contrast, the two month-old homozygote (B) shows a number of abnormalities, with numerous outer hair cells missing and punctate staining of prestin in many of the remaining cells. The stereocilia of inner hair cells, on the other hand, are still clearly visible in red on the right side of the image, though the phalloidin staining of the supporting cells between the inner and outer hair cells is substantially reduced.

Copyright

This image is from Probst FJ, PLoS One 2013;8(11):e80408, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:209766

Associated Alleles

Symbol	Name
Alg10b^nse5	ALG10 alpha-1,2-glucosyltransferase; neurological/sensory 5

Associated Genotypes

Allelic Composition	Genetic Background
Alg10b^nse5/Alg10b^nse5	129S6.B6-Alg10b^nse5