Phenotype Image Detail

Image

Caption

(B) Knee joints from Errfi1^tm3.1Gvw/Errfi1⁺Tg(Col2a1-cre)1Asz/0 (Mig6^flox/+;Col2a1^Cre) mice and Errfi1^tm3.1Gvw/Errfi1^tm3.1Gvw Tg(Col2a1-cre)1Asz/0 (Mig6^flox/flox;Col2a1^Cre) mice mice at the indicated ages. (C) Ankles from Errfi1^tm3.1Gvw/Errfi1⁺Tg(Col2a1-cre)1Asz/0 (Mig6^flox/+;Col2a1^Cre) mice and Errfi1^tm3.1Gvw/Errfi1^tm3.1Gvw Tg(Col2a1-cre)1Asz/0 (Mig6^flox/flox;Col2a1^Cre) mice at 15.3 months, and from Errfi1^tm3.1Gvw/Errfi1⁺ Tg(CMV-cre)1Cgn/0 (Mig-6^delta/+;CMV^cre) and Errfi1^tm3.1Gvw/Errfi1^tm3.1Gvw Tg(CMV-cre)1Cgn/0 (Mig-6^delta/delta;CMV^Cre) mice at 3.7 months. (D) Temporal-mandibular joints (TMJs) from Errfi1^tm3.1Gvw/Errfi1⁺Tg(Col2a1-cre)1Asz/0 (Mig6^flox/+;Col2a1^Cre) mice and Errfi1^tm3.1Gvw/Errfi1^tm3.1Gvw Tg(Col2a1-cre)1Asz/0 (Mig6^flox/flox;Col2a1^Cre) mice at 3 and 6 months, from Errfi1⁺/Errfi1^tm1Gvw (Mig-6^+/-) and Errfi1^tm1Gvw/Errfi1^tm1Gvw (Mig-6^-/-) mice at 1 month, and from a Errfi1^tm3.1Gvw/Errfi1^tm3.1Gvw Tg(CMV-cre)1Cgn/0 mouse at 3.6 months. Osteophytes are indicated by "Nod" and subchondral cysts by "Cyst".

Copyright

This image is from Staal B, Proc Natl Acad Sci U S A 2014 Feb 18;111(7):2590-5. Copyright 2014 National Academy of Sciences, U.S.A. J:206807

Associated Alleles

Symbol	Name
Errfi1^tm3.1Gvw	ERBB receptor feedback inhibitor 1; targeted mutation 3.1, George F Vande Woude
Tg(CMV-cre)1Cgn	transgene insertion 1, University of Cologne
Tg(Col2a1-cre)1Asz	transgene insertion 1, Attila Aszodi

Associated Genotypes

Allelic Composition	Genetic Background
Errfi1^tm3.1Gvw/Errfi1^tm3.1Gvw Tg(Col2a1-cre)1Asz/0	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * CBA
Errfi1^tm3.1Gvw/Errfi1^tm3.1Gvw Tg(CMV-cre)1Cgn/0	involves: 129 * 129S4/SvJaeSor * BALB/cJ