Phenotype Image Detail

Image

Caption

Chondrocyte-specific deletion of Errfi1 (Mig-6) resulted in thickening of articular cartilage accompanying increase of chondrocyte numbers. (A) Representative knee joints of the Errfi1^tm3.1Gvw/Errfi1⁺ Tg(Col2a1-cre)1Asz/0 (Mig-6^flox/flox;Col2a1^Cre) and Errfi1^tm3.1Gvw/Errfi1^tm3.1Gvw Tg(Col2a1-cre)1Asz/0 (Mig-6^flox/flox;Col2a1^Cre) mice (age 16.1 months) are shown. The arrows indicate the tidemarks, and the yellow bars measure the distance between the tidemark and the surface of the articular cartilage.

Copyright

This image is from Staal B, Proc Natl Acad Sci U S A 2014 Feb 18;111(7):2590-5. Copyright 2014 National Academy of Sciences, U.S.A. J:206807

Associated Alleles

Symbol	Name
Errfi1^tm3.1Gvw	ERBB receptor feedback inhibitor 1; targeted mutation 3.1, George F Vande Woude
Tg(Col2a1-cre)1Asz	transgene insertion 1, Attila Aszodi

Associated Genotypes

Allelic Composition	Genetic Background
Errfi1^tm3.1Gvw/Errfi1^tm3.1Gvw Tg(Col2a1-cre)1Asz/0	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * CBA