Phenotype Image Detail

Image

Caption

Pathological analysis of non-surviving Pdlim7^{Gt(OST445990)Lex}/Pdlim7^{Gt(OST445990)Lex} (-/-) and Pdlim7^{Gt(OST445990)Lex}/Pdlim7⁺ (+/-) pups reveals pre-mortem thrombi. Heterozygous (n=3) and homozygous (n=11) mutant perinatal lethal pups exhibit extensive blood clots in the heart, arteries (arrowhead), and veins (arrows, B-C') associated with atrial dilation and lung congestion compared to wild-type (+/+) (n=7) controls (A-A'). Example of pre-mortem blood clots in the right ventricle (E-E'), umbilical vessel (G-G'), and lung alveoli (I-I') of a homozygous mutant perinatal lethal pup compared to wild-type control (D, F, H). Boxes depict location of high magnification image in E', G', and I'. Arrows point to attachment of the thrombus to the vessel wall (E', I') and arrowhead points to recanalization of the clot (G'). Scale bar = 1 mm (A-C'), 50 um (D-I), 20 um (G', I'), and 10 um (E').

Copyright

This image is from Krcmery J, PLoS One 2013;8(11):e80809, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:209780

Associated Alleles

Symbol	Name
Pdlim7^Gt(OST445990)Lex	PDZ and LIM domain 7; gene trap OST445990, Lexicon Genetics

Associated Genotypes

Allelic Composition	Genetic Background
Pdlim7^Gt(OST445990)Lex/Pdlim7^Gt(OST445990)Lex	B6.129S5-Pdlim7^Gt(OST445990)Lex