Phenotype Image Detail

Image

Caption

Prdm6 affects angiogenic patterning. (A) Unusual clusters of densely growing vessel structures on yolk sacs of Prdm6^tm1.2Jrld/Prdm6^tm1.2Jrld (del/del) embryos, as observed under a stereomicroscope. Scale bars correspond to 1 mm (left panel) or 100 um (right panel). (B) Large vessels in the yolk sacs of E12.5 control and mutant embryos under a stereomicroscope. Scale bars correspond to 500 um. (C) Visualization of E10.5 (left panels) and E11.5 (right panels) yolk sac microvascular systems via immunofluorescent staining with an anti-CD31 primary antibody and a Cy3-conjugated secondary antibody. Scale bars correspond to 200 um. (D) Quantitative morphometric analysis of the yolk sac vasculature as shown in (C). Avascular space and mean vessel diameters of yolk sacs at E10.5-E11.5 are shown as mean SEM, n=6.

Copyright

This image is from Gewies A, PLoS One 2013;8(11):e81833, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:209773

Associated Alleles

Symbol	Name
Prdm6^tm1.2Jrld	PR domain containing 6; targeted mutation 1.2, Jurgen Ruland

Associated Genotypes

Allelic Composition	Genetic Background
Prdm6^tm1.2Jrld/Prdm6^tm1.2Jrld	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL