Phenotype Image Detail

Image

Caption

Sel1l^{tm1c(KOMP)Wtsi}/Sel1l^{tm1c(KOMP)Wtsi} Tg(CAG-cre/Esr1*)5Amc/0 (IKO) mice develop exocrine pancreatic insufficiency and nutrient malabsorption. Mice were analyzed at 13 days after the first tamoxifen injection. (A) H&E images of mutant pancreas, showing lymphocyte infiltration. Arrows indicate neutrophils and lymphocytes. n = 3-5 each group. (B) Plasma insulin and glucagon levels. n = 5 each. (C) Representative immunohistochemical staining of insulin and glucagon on the pancreatic sections. n = 3-5 each group.

Copyright

This image is from Sun S, Proc Natl Acad Sci U S A 2014 Feb 4;111(5):E582-91. Copyright 2014 National Academy of Sciences, U.S.A. J:206568

Associated Alleles

Symbol	Name
Sel1l^tm1c(KOMP)Wtsi	sel-1 suppressor of lin-12-like (C. elegans); targeted mutation 1c, Welcome Trust Sanger Institute
Tg(CAG-cre/Esr1*)5Amc	transgene insertion 5, Andrew P McMahon

Associated Genotypes

Allelic Composition	Genetic Background
Sel1l^tm1c(KOMP)Wtsi/Sel1l^tm1c(KOMP)Wtsi Tg(CAG-cre/Esr1*)5Amc/0	involves: C57BL/6 * C57BL/6N * CBA * SJL