Phenotype Image Detail

Image

Caption

Characteristic caudal mass/ectopic limb phenotypes in Etn3^tm2.1Jwi/Etn3⁺ offspring. A. (one panel) Bruce4.G9 targeted ES cell clone (9281)-derived chimeric male produced a female heterozygous carrier that was mated to a beta-actin FLPe male to produce the newborn mutant shown in the panel here. Genotyping confirmed the proper FLPe recombination fragment demonstrating Neo cassette removal in this mouse. B., C. Typical caudal masses with ectopic limbs in offspring of mutant mice. 9 out of 69 offspring from mating between mutant males X B6/D2 F1 females demonstrated typical caudal masses/ectopic limbs (3 panels in B), whereas 8 out of 31 offspring from mating between mutant males X FVB females demonstrated typical caudal masses and in one mouse a bifurcated tail seen at birth and later at 3 weeks (5 panels in C).

Copyright

This image is from Lehoczky JA, PLoS Genet 2013 Dec;9(12):e1003967, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:207896

Associated Alleles

Symbol	Name
Etn3^tm1.1Jwi	early transposon element insertion site 3; targeted mutation 1.1, Jeffrey W Innis

Associated Genotypes

Allelic Composition	Genetic Background
Etn3^tm1.1Jwi/Etn3^+	involves: C57BL/6 * DBA/2
Etn3^tm1.1Jwi/Etn3^+	involves: C57BL/6 * FVB