Phenotype Image Detail

Image

Caption

P3h2^tm1Hpb/P3h2^tm1Hpb (P3H2 null) and normal littermates at 6.5 d postconception. (A and B) Isolated embryos at E6.5. Both embryos appear morphologically normal. Arrowheads are pointing to the maternal blood neighboring embryos. There is a blood clot in close proximity to the embryo seen in B. Representative sections of normal and mutant E6 deciduae are shown unstained (C and D) and stained with the Wright's stain (E and F). Arrowheads indicate maternal blood invading the ectoplacental cone. Thrombus formation next to the mutant embryo (E) is observed in D and F. Wright's stain visualizes maternal platelets in purple (F, arrowhead). Note that erythrocytes appear orange to pink and are difficult to differentiate from the purple platelets. (Scale bars: A and B, 200 um; C-F, 100 um.)

Copyright

This image is from Pokidysheva E, Proc Natl Acad Sci U S A 2014 Jan 7;111(1):161-6. Copyright 2014 National Academy of Sciences, U.S.A. J:206377

Associated Alleles

Symbol	Name
P3h2^tm1Hpb	prolyl 3-hydroxylase 2; targeted mutation 1, Hans Peter Bachinger

Associated Genotypes

Allelic Composition	Genetic Background
P3h2^tm1Hpb/P3h2^tm1Hpb	involves: 129 * C57BL/6J