Phenotype Image Detail

Image

Caption

SVS2-mediated protection of intrauterine sperm from membrane disruption. (A) Transmission electron microscopic (TEM) images of sperm from Semg1^tm1Kemi/Semg1^tm1Kemi Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 or Semg1^tm2Kemi/Semg1^tm2Kemi Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 mice. Diagram at far left indicates the orientation of sectioned heads of sperm. (Left) Sperm with SVS2; (Center) sperm with SVS2; (Right) sperm without SVS2. (Left, Center, and Right) Right upper and middle images are enlarged views of boxes in the left images, and diagrams are depicted in the right lower images. PM, plasma membrane; N, nucleus; NM, nuclear membrane. (Scale bars: 1 um.) (Center, Inset) A fluorescent image of the sperm reacted with anti-SVS2 pAb. (Scale bar, 5 um.)

Copyright

This image is from Kawano N, Proc Natl Acad Sci U S A 2014 Mar 18;111(11):4145-50. Copyright 2014 National Academy of Sciences, U.S.A. J:207389

Associated Alleles

Symbol	Name
Semg1^tm1Kemi	semenogelin 1; targeted mutation 1, Kenji Miyado
Semg1^tm2Kemi	semenogelin 1; targeted mutation 2, Kenji Miyado
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb	transgene insertion RBGS002, Research Institute for Microbial Diseases, Osaka University

Associated Genotypes

Allelic Composition	Genetic Background
Semg1^tm1Kemi/Semg1^tm1Kemi Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0	involves: 129 * C57BL/6 * C57BL/6N * DBA/2
Semg1^tm2Kemi/Semg1^tm2Kemi Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0	involves: 129 * C57BL/6 * C57BL/6N * DBA/2