Phenotype Image Detail

Image

Caption

Spon1^tm1Gdpa/Spon1^tm1Gdpa (KO) mice have increased trabecular and cortical bone. (A) Representative 3D microCT images showing regions of trabecular bone in the distal femur (F) and proximal tibia (T). Graphs represent measurements of total body weight (g), trabecular bone volume (bone volume per tissue volume, BV/TV), trabecular number (Tb.N/mm) and trabecular spacing (Tb.sp/mm) in the femurs and tibiae of 3 month (n = 4), 6 month (n = 10-11) and 12 month (n = 6) -old mutant and wild-type (WT) mice. (B) Representative 3D microCT images showing regions of femoral cortical bone in WT and KO mice. Graph represents measurement of total area (Tt.Ar mm²), cortical area (Ct.Ar mm²), cortical thickness (Ct.Th/mm) and intra-cortical porosity (%) of 6 month (n = 6-11) and 12 month (n = 5) mice. Arrows show the irregular surfaces along the endosteal perimeters of KO mice. Statistically significant differences from WT mice groups are indicated by *(P<0.05).

Copyright

This image is from Palmer GD, PLoS One 2014;9(5):e98388, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:214251

Associated Alleles

Symbol	Name
Spon1^tm1Gdpa	spondin 1, (f-spondin) extracellular matrix protein; targeted mutation 1, Glyn D Palmer

Associated Genotypes

Allelic Composition	Genetic Background
Spon1^tm1Gdpa/Spon1^tm1Gdpa	Not Specified