Phenotype Image Detail

Image

Caption

Histological evidence of myopathy in 8-10-month-old Apobec2^tm1Msn/Apobec2^tm1Msn (A2-/-) mice. A, examples of a region of soleus muscle (SL) in 15-week-old wild-type (WT) or mutant mice. The arrowheads indicate fibers with centrally located nuclei, and the right panel shows a region with immature myotubes. B, comparison of transverse sections of vastus and rectus femoris (VRL), gastrocnemius (GT), and extensorum digitorum longus (EDL) muscle from 9-month-old mutant and WT mice. The boxed areas in the middle panels are shown in higher magnification in the right panels, where outlined regions contain smaller fibers. C, histogram comparing the percentage of centrally nucleated fibers (CNF) in different muscles from 9-month-old mutant and control mice.

Copyright

This image is from Sato Y, J Biol Chem 2010 Mar 5;285(10):7111-8 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:221028

Associated Alleles

Symbol	Name
Apobec2^tm1Msn	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2; targeted mutation 1, Michael S Neuberger

Associated Genotypes

Allelic Composition	Genetic Background
Apobec2^tm1Msn/Apobec2^tm1Msn	B6.129P2-Apobec2^tm1Msn