Phenotype Image Detail

Image

Caption

Morphological and radiographic examination of Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba} mice. A) 2-week-old mutant mice are growth retarded. 2-week-old mutant mice (C and E) also have a tooth eruption defect compared to their wild-type (WT) littermates (B and D). The white arrows (D and E) demonstrate the presence of tooth buds that failed to erupt in the mutant mice. Radiographic images demonstrate that 3-week-old mutant mice (G and I) have bones that lack marrow cavities. Compare the femur (white arrow) and pelvis (black arrow) with WT (F and H) mice. The metaphyseal cupping in the mutant femur and tibia (I) are consistent with rickets.

Copyright

This image is from Ye L, PLoS Genet 2015 Mar;11(3):e1005057, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:224711

Associated Alleles

Symbol	Name
Snx10^tm1a(EUCOMM)Raba	sorting nexin 10; targeted mutation 1a, Ricardo A Battaglino

Associated Genotypes

Allelic Composition	Genetic Background
Snx10^tm1a(EUCOMM)Raba/Snx10^tm1a(EUCOMM)Raba	involves: 129S4/SvJae * C57BL/6 * C57BL/6J