Phenotype Image Detail

Image

Caption

MicroCT analysis of Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba} (Snx10 KD) mice. (A, top) Surface images of the femur demonstrate a deficiency of mineralized cortical bone. Longitudinal mid-plane images of the femur (A, bottom) show a marrow cavity filled with unresorbed bone in mutant mice. Other examined bones: head, (B) and mandible (C) also were deficient in cortical bone, producing a moth-eaten appearance. Cross sectional microCT images of femur (D, E, F and G) reveal the presence of an inner ring of cortex-like (i.e., denser) bone in mutant bones (E and G).

Copyright

This image is from Ye L, PLoS Genet 2015 Mar;11(3):e1005057, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:224711

Associated Alleles

Symbol	Name
Snx10^tm1a(EUCOMM)Raba	sorting nexin 10; targeted mutation 1a, Ricardo A Battaglino

Associated Genotypes

Allelic Composition	Genetic Background
Snx10^tm1a(EUCOMM)Raba/Snx10^tm1a(EUCOMM)Raba	involves: 129S4/SvJae * C57BL/6 * C57BL/6J