Phenotype Image Detail

Image

Caption

C) 3-week-old Ctsk^tm1(cre)Ska/Ctsk^tm1(cre)Ska Snx10^{tm1c(EUCOMM)Raba}/Snx10^{tm1c(EUCOMM)Raba} (CatK; Snx10 fl/fl) mice are growth retarded. E and G) 3-week-old mutants have a tooth eruption defect compared to their wild-type (WT) littermates (D and F). Radiographs (I and L) show that 3-week-old mutant mice have bones without marrow spaces and with a higher radio-density than WT counterparts (H and K) or Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba} (Snx10 KD) (J and M). The metaphyseal fraying and cupping seen in the Snx10 KD femur and tibia are not observed in the conditional mutant mice (I and L), consistent with osteopetrosis with no rickets.

Copyright

This image is from Ye L, PLoS Genet 2015 Mar;11(3):e1005057, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:224711

Associated Alleles

Symbol	Name
Ctsk^tm1(cre)Ska	cathepsin K; targeted mutation 1, Shigeaki Kato
Snx10^tm1c(EUCOMM)Raba	sorting nexin 10; targeted mutation 1c, Ricardo A Battaglino

Associated Genotypes

Allelic Composition	Genetic Background
Ctsk^tm1(cre)Ska/Ctsk^+ Snx10^tm1c(EUCOMM)Raba/Snx10^tm1c(EUCOMM)Raba	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj