Phenotype Image Detail

Image

Caption

Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba} (Snx10 KD) mice display reduced zymogenic cell granular size and abundance. A) Immunofluorescence images from stomach sections from wild-type (WT) and mutant mice stained for GIF (a zymogenic cell marker, ZC), Snx10, GSII (a marker for the mucous neck cells interspersed with the parietal cells in the neck of the gastric unit) shows Snx10-specific staining in WT zymogenic cells. B) H&E confirms the small size and high nuclear:cytoplasmic ratio of parietal cells in mutant gastric units. The zymogenic cells, lacking their abundant apical granules, are also smaller, and there are increased parietal cells in the base (ZC) zone (black arrowheads).

Copyright

This image is from Ye L, PLoS Genet 2015 Mar;11(3):e1005057, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:224711

Associated Alleles

Symbol	Name
Snx10^tm1a(EUCOMM)Raba	sorting nexin 10; targeted mutation 1a, Ricardo A Battaglino

Associated Genotypes

Allelic Composition	Genetic Background
Snx10^tm1a(EUCOMM)Raba/Snx10^tm1a(EUCOMM)Raba	involves: 129S4/SvJae * C57BL/6 * C57BL/6J