Phenotype Image Detail

Image

Caption

Embryos from Ptbp1^tm1Msol heterozygous parents fall into 2 size categories. Hematoxylin and eosin stained decidual sections of 2 litters were analysed for surface area and structural organisation. Embryos were grouped according to their developmental stage (left) with the furthest developed having reached neural plate stage but most embryos being at the primitive streak stage. The surface area of the embryos in the middle section was measured with the Fiji image software and ranked according to size, which turned out as equivalent to stage (right). Presumedknockouts (red) were significantly smaller than wild-type or heterozygous controls and present in a roughly Mendelian ratio of 3:10 (ratio 0.3 vs. the expected 0.25). The size of the small embryos might have even been overestimated since it was harder to recognise the embryo in those implantations. We also encountered 2 decidua with no visible embryonic structures.

Copyright

This image is from Suckale J, PLoS One 2011;6(2):e16992, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:223915

Associated Alleles

Symbol	Name
Ptbp1^tm1Msol	polypyrimidine tract binding protein 1; targeted mutation 1, Michele Solimena

Associated Genotypes

Allelic Composition	Genetic Background
Ptbp1^tm1Msol/Ptbp1^tm1Msol	B6J.129-Ptbp1^tm1Msol