Phenotype Image Detail

Image

Caption

B) Serial paraffin sections of wild-type (WT) and Ptbp1^tm1Msol/Ptbp1^tm1Msol (KO) E7.5 embryos were stained with hematoxylin and eosin (left column) or labelled with DAPI (middle column) and the PTBP1 antibody (right column). The top row shows a large embryo (in an oblique section) with strong nuclear PTBP1 staining of the embryo proper (dashed line) and the surrounding tissue. Both small embryos were characterised by a lack of the nuclear PTBP1 signal while showing nuclear PTBP1 in surrounding, most likely maternal cells. Interpretative diagrams and a quantification of the embryo section area are shown on the right.

Copyright

This image is from Suckale J, PLoS One 2011;6(2):e16992, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:223915

Associated Alleles

Symbol	Name
Ptbp1^tm1Msol	polypyrimidine tract binding protein 1; targeted mutation 1, Michele Solimena

Associated Genotypes

Allelic Composition	Genetic Background
Ptbp1^tm1Msol/Ptbp1^tm1Msol	B6J.129-Ptbp1^tm1Msol