Phenotype Image Detail

Image

Caption

Comparison of craniofacial skeletons among E15.5 Ednra^tm2.1Hku/Ednra^tm2.1Hku (Ednra^lacZ/lacZ) (A), wild-type (WT) (B) and Ednra^tm6(Edn1)Hku/Ednra⁺ (Ednra^Edn1/+) (C) mice. Activated Edn1/Ednra signaling (colored in pink) correlates to the formation of Meckelian cartilage (MC) and associated mandibular structures. at, ala temporalis; dnt, dentary; hy, hyoid; in, incus; ma, malleus; mx, maxilla; pl, palatine; pmx, premaxilla; *, ectopic structure.

Copyright

This image is from Sato T, Proc Natl Acad Sci U S A 2008 Dec 2;105(48):18806-11. Copyright 2008 National Academy of Sciences, U.S.A. J:224515

Associated Alleles

Symbol	Name
Ednra^tm2.1Hku	endothelin receptor type A; targeted mutation 2.1, Hiroki Kurihara
Ednra^tm6(Edn1)Hku	endothelin receptor type A; targeted mutation 6, Hiroki Kurihara

Associated Genotypes

Allelic Composition	Genetic Background
Ednra^tm2.1Hku/Ednra^tm2.1Hku	involves: 129 * C57BL/6 * ICR
Ednra^tm6(Edn1)Hku/Ednra^+	involves: 129 * C57BL/6 * ICR