Phenotype Image Detail

Image

Caption

Skeletal components of E15.5 wild-type (WT) and Ednra^tm6(Edn1)Hku/Ednra⁺ (Ednra^Edn1) jaws. (A-C) Cranial views of the nasomaxillary region in E15.5 Ednra^tm2.1Hku/Ednra^tm2.1Hku (Ednra^lacZ/lacZ) (A), WT (B), and Ednra^tm6(Edn1)Hku/Ednra⁺ (Ednra^Edn1/+) (C) mice. Mandibular-to-maxillary and maxillary-to-mandibular transformations are observed in Ednra^lacZ/lacZ and Ednra^Edn1/+ mutants, respectively. Midline structures such as the nasal capsule and the trabecular plate are well formed in both mutants. (D-I) PA1-derived skeletons of WT (D and E) and Ednra^Edn1/+ (F-I) mice. The duplicated Meckel's cartilage (MC) extends beyond the ectopic dentary bone forming laterally to it, as in case with their orthotopic counterparts. The ectopic MC is discontinuous to the transformed incus-malleus in some cases (H), but is continuous to it in other cases (I). at, ala temporalis; dnt, dentary; in, incus; ma, malleus; MC, Meckel's cartilage; mx, maxilla; nsc, nasal capsule; pl, palatine; pmx, premaxilla; ps, presphenoid; tp, trabecular plate; *, ectopic structure.

Copyright

This image is from Sato T, Proc Natl Acad Sci U S A 2008 Dec 2;105(48):18806-11. Copyright 2008 National Academy of Sciences, U.S.A. J:224515

Associated Alleles

Symbol	Name
Ednra^tm2.1Hku	endothelin receptor type A; targeted mutation 2.1, Hiroki Kurihara
Ednra^tm6(Edn1)Hku	endothelin receptor type A; targeted mutation 6, Hiroki Kurihara

Associated Genotypes

Allelic Composition	Genetic Background
Ednra^tm2.1Hku/Ednra^tm2.1Hku	involves: 129 * C57BL/6 * ICR
Ednra^tm6(Edn1)Hku/Ednra^+	involves: 129 * C57BL/6 * ICR
Ednra^tm2.1Hku/Ednra^+	involves: 129 * C57BL/6 * ICR