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Caption | Skeletal abnormalities of Ednratm7(Hand2)Hku/Ednra+ (EdnraHand2/+) ES cell-derived chimeras at E16.5. (A and A'-D and D') Representative bone and cartilage morphology of E16.5 wild-type (WT) (A and A') and mutant chimeric (B and B'-D and D') mice. Mutant chimeras demonstrate craniofacial abnormalities and mirror-image polydactyly (B-D). Some mutant chimeras with polydactyly show transformation of the maxilla into dentary-like morphology without Meckelian cartilage (MC) formation (B'). Others exhibit ectopic formation of MC-like rod-shaped cartilage in the maxilla with (C') or without (D') the ala temporalis. In severely affected chimeras, the gonial, ectotympanic, squamosal, and lamina obturans were deformed (C) or almost missing (D). at, ala temporalis; dnt, dentary; etm, ectotympanic; gn, gonial; in, incus; jg, jugal; lo, lamina obturans; ma, malleus; MC, Meckel's cartilage; mx, maxilla; pmx, premaxilla; sp, styloid process; sq, squamosal; st, stapes; *, ectopic structure. | ||||
Copyright | This image is from Sato T, Proc Natl Acad Sci U S A 2008 Dec 2;105(48):18806-11. Copyright 2008 National Academy of Sciences, U.S.A. J:224515 | ||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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