Phenotype Image Detail

Image

Caption

Defective formation of the pelvic/urogenital organs in Bmp4^tm4Blh/Bmp4^tm4Blh Isl1^tm1(cre)Sev/Isl1⁺ (Bmp4 cKO) mice. (A-F) Mutant mice have bladder aplasia (red arrow in B) and hypoplastic kidney (yellow arrowheads in B), hypoplasia of external genitalia (arrow in D) and anal stenosis (arrowhead in F). red arrow, bladder; yellow arrowhead, kidney; arrow, genital tubercle; arrowhead, ano-rectal region.

Copyright

This image is from Suzuki K, PLoS One 2012;7(9):e43453, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:192045

Associated Alleles

Symbol	Name
Bmp4^tm4Blh	bone morphogenetic protein 4; targeted mutation 4, Brigid L Hogan
Isl1^tm1(cre)Sev	ISL1 transcription factor, LIM/homeodomain; targeted mutation 1, Sylvia Evans

Associated Genotypes

Allelic Composition	Genetic Background
Bmp4^tm4Blh/Bmp4^tm4Blh Isl1^tm1(cre)Sev/Isl1^+	involves: 129 * 129S6/SvEvTac