Phenotype Image Detail

Image

Caption

Defective anterior peri-cloacal mesenchyme (aPCM) formation of Bmp4^tm4Blh/Bmp4^tm4Blh Isl1^tm1(cre)Sev/Isl1⁺ (Bmp4 cKO) mice. (A) Bmp4 is expressed in the aPCM at E10.5. (B) Immunohistochemical analysis of pSMAD in the aPCM at E10.5. (C-J) Section in situ hybridization analysis with the aPCM and cloacal marker genes for wild type (WT) (C, E, G, I) and mutant embryos (D, F, H, J) at E10.5. (K-N) Immunohistochemical analysis of pSMAD in the aPCM of WT (K) and mutant embryos (L) at E10.5. (M, N) High magnification images of square region in K and L. The squares in A-L indicate the aPCM.

Copyright

This image is from Suzuki K, PLoS One 2012;7(9):e43453, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:192045

Associated Alleles

Symbol	Name
Bmp4^tm4Blh	bone morphogenetic protein 4; targeted mutation 4, Brigid L Hogan
Isl1^tm1(cre)Sev	ISL1 transcription factor, LIM/homeodomain; targeted mutation 1, Sylvia Evans

Associated Genotypes

Allelic Composition	Genetic Background
Bmp4^tm4Blh/Bmp4^tm4Blh Isl1^tm1(cre)Sev/Isl1^+	involves: 129 * 129S6/SvEvTac