Phenotype Image Detail

Image

Caption

Skeletal effects of osteoblast expression of Tg(tetO-HTR4*D100A)7Niss by microCT. (A-C) Whole-body CT analysis of Tg(Col1a1-tTA)139Niss/0 Tg(tetO-HTR4*D100A)7Niss/0 (Coll(2.3)+/Rs1+) mice and wild-type (WT) littermate controls (50-um resolution) shows dramatically enhanced bone accumulation in double transgenic mice that progresses with age. (D) Femurs from WT and double transgenic mice, illustrating the increase in bone width and effacement of cortical bone. Note that the articular surfaces of the bones appear minimally affected. (E) Cross-sectional CT images (10-um resolution) of femurs from WT (Left) and mutant (Right) mice show a predominance of trabecular bone with effacement of the cortical shell in double transgenic mice.

Copyright

This image is from Hsiao EC, Proc Natl Acad Sci U S A 2008 Jan 29;105(4):1209-14. Copyright 2008 National Academy of Sciences, U.S.A. J:131617

Associated Alleles

Symbol	Name
Tg(Col1a1-tTA)139Niss	transgene insertion 139, Robert Nissenson
Tg(tetO-HTR4*D100A)7Niss	transgene insertion 7, Robert A Nissenson

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Col1a1-tTA)139Niss/0 Tg(tetO-HTR4*D100A)7Niss/0	FVB/N-Tg(Col1a1-tTA)139Niss Tg(tetO-HTR4*D100A)7Niss