Phenotype Image Detail

Image

Caption

Histomorphometry of Tg(Col1a1-tTA)139Niss/0 Tg(tetO-HTR4*D100A)7Niss/0 (Coll(2.3)+/Rs1+) femurs from 3-week old mice. (A and B) Histomorphometry of femurs at 3 weeks of age by von Kossa/tetrachrome staining shows disorganized trabeculi and a population of uniform cells replacing the normal bone marrow and lining the surface of the trabeculi. (C and D) Bone mineral apposition assessed by dual fluorochrome also shows a disordered growth pattern in the mutant mice, similar to that seen in 9-week-old mice. (E and F) TRAP staining also suggests increased osteoclast activity consistent with the increased bone surface. (Scale bars, 50 mm.)

Copyright

This image is from Hsiao EC, Proc Natl Acad Sci U S A 2008 Jan 29;105(4):1209-14. Copyright 2008 National Academy of Sciences, U.S.A. J:131617

Associated Alleles

Symbol	Name
Tg(Col1a1-tTA)139Niss	transgene insertion 139, Robert Nissenson
Tg(tetO-HTR4*D100A)7Niss	transgene insertion 7, Robert A Nissenson

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Col1a1-tTA)139Niss/0 Tg(tetO-HTR4*D100A)7Niss/0	FVB/N-Tg(Col1a1-tTA)139Niss Tg(tetO-HTR4*D100A)7Niss