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Caption | Histomorphometry of Tg(Col1a1-tTA)139Niss/0 Tg(tetO-HTR4*D100A)7Niss/0 (Coll(2.3)+/Rs1+) femurs from 3-week old mice. (A and B) Histomorphometry of femurs at 3 weeks of age by von Kossa/tetrachrome staining shows disorganized trabeculi and a population of uniform cells replacing the normal bone marrow and lining the surface of the trabeculi. (C and D) Bone mineral apposition assessed by dual fluorochrome also shows a disordered growth pattern in the mutant mice, similar to that seen in 9-week-old mice. (E and F) TRAP staining also suggests increased osteoclast activity consistent with the increased bone surface. (Scale bars, 50 mm.) | ||||||
Copyright | This image is from Hsiao EC, Proc Natl Acad Sci U S A 2008 Jan 29;105(4):1209-14. Copyright 2008 National Academy of Sciences, U.S.A. J:131617 | ||||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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