Phenotype Image Detail

Image

Caption

H&E staining of the gastrocnemius muscle of wild-type (CTL) and Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0 Meox2^tm1(cre)Sor/Meox2⁺ (CAG-FUST^WT) and Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0 Meox2^tm1(cre)Sor/Meox2⁺ (CAG-FUS^R521G) mice at end stage show wasting of the muscle and scattered and grouped muscle atrophy, characteristic of motor axon degeneration. Arrowheads indicate pyknotic myofibers. Images are representative of three animals per genotype.

Copyright

This image is from Sephton CF, Proc Natl Acad Sci U S A 2014 Nov 4;111(44):E4769-78. Copyright 2014 National Academy of Sciences, U.S.A. J:216672

Associated Alleles

Symbol	Name
Meox2^tm1(cre)Sor	mesenchyme homeobox 2; targeted mutation 1, Philippe Soriano
Tg(CAG-lacZ,-FUS,-EGFP)629Gyu	transgene insertion 629, Gang Yu
Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu	transgene insertion 682, Gang Yu

Associated Genotypes

Allelic Composition	Genetic Background
Meox2^tm1(cre)Sor/Meox2^+ Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0	involves: 129S4/SvJaeSor * C57BL/6
Meox2^tm1(cre)Sor/Meox2^+ Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0	involves: 129S4/SvJaeSor * C57BL/6