Phenotype Image Detail

Image

Caption

Costaining for presynaptic terminals (nerve; red) and with bungarotoxin for postsynaptic terminals (AchR; green) shows that neuromuscular junctions (NMJs) are denervated in P20-P24 Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0 Meox2^tm1(cre)Sor/Meox2⁺ (CAG-FUS^WT) and Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0 Meox2^tm1(cre)Sor/Meox2⁺ (CAG-FUS^R521G) mice at end stage compared with littermate controls (CTL).

Copyright

This image is from Sephton CF, Proc Natl Acad Sci U S A 2014 Nov 4;111(44):E4769-78. Copyright 2014 National Academy of Sciences, U.S.A. J:216672

Associated Alleles

Symbol	Name
Meox2^tm1(cre)Sor	mesenchyme homeobox 2; targeted mutation 1, Philippe Soriano
Tg(CAG-lacZ,-FUS,-EGFP)629Gyu	transgene insertion 629, Gang Yu
Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu	transgene insertion 682, Gang Yu

Associated Genotypes

Allelic Composition	Genetic Background
Meox2^tm1(cre)Sor/Meox2^+ Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0	involves: 129S4/SvJaeSor * C57BL/6
Meox2^tm1(cre)Sor/Meox2^+ Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0	involves: 129S4/SvJaeSor * C57BL/6