Phenotype Image Detail

Image

Caption

Phenotypes observed in 3-week-old GT/Le mgi:1856893/mgi:1856893 (gt/gt) mice. a, b: Pigmentation phenotypes of mutant mice include dilution of pheomelanin (yellow pigment) in coat hairs, giving them a grayish appearance, a white forehead blaze, a white belly and white feet. c: Intestines of two mutant mice, showing one with megacolon and an age-matched sibling that is unaffected. d: H&E-stained paraffin sections of the brains of wild-type and mutant animals showing typical pattern of vacuolation in mutant cerebellum, pons, thalamus and hippocampus. ML molecular layer, GL granule layer, WM white matter. All panels at same magnification, scale bar 5 um. e: Central nervous system (CNS) vacuolation in mutant brains is associated with gliosis, as revealed by immunohistochemistry (IHC) for glial fibrillary acidic protein (GFAP). All panels at same magnification, scale bar 10 um.

Copyright

This image is from Anderson SR, Mamm Genome 2014 Nov 16;(): and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:216967

Associated Alleles

Symbol	Name
Sox10^gt	SRY (sex determining region Y)-box 10; gray tremor

Associated Genotypes

Allelic Composition	Genetic Background
Sox10^gt/Sox10^gt	GT/Le