Phenotype Image Detail

Image

Caption

b) A P4 Sox10^gt/Sox10^tm1Weg (gt/Sox10^LacZ) pup shown with its Sox10^tm1Weg/Sox10⁺ (Sox10^LacZ/⁺), Sox10^gt/Sox10⁺ (gt/⁺), and wild-type siblings. c) Lack of pigmentation in the compound heterozygote Sox10^gt/Sox10^tm1Weg reflects a lack of skin melanocytes, as shown by X-galactosidase staining. d) Mutant compound heterozygotes exhibit a distended belly, indicative of megacolon.

Copyright

This image is from Anderson SR, Mamm Genome 2014 Nov 16;(): and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:216967

Associated Alleles

Symbol	Name
Sox10^gt	SRY (sex determining region Y)-box 10; gray tremor
Sox10^tm1Weg	SRY (sex determining region Y)-box 10; targeted mutation 1, Michael Wegner

Associated Genotypes

Allelic Composition	Genetic Background
Sox10^gt/Sox10^tm1Weg	involves: 129S1/Sv * 129X1/SvJ * GT/Le