Phenotype Image Detail

Image

Caption

Electron microscopy shows abnormal cellular morphology and collagen retention of mouse embryonic fibroblasts (MEFs). Fkbp10^{tm2a(EUCOMM)Wtsi}/Fkbp10^{tm2a(EUCOMM)Wtsi} cells show dilated endoplasmic reticulum (ER) with embedded matrix as well as intracytoplasmic collagen fibers (shown by arrows).

Copyright

This image is from Lietman CD, Hum Mol Genet 2014 Sep 15;23(18):4822-31, an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License. J:213596

Associated Alleles

Symbol	Name
Fkbp10^tm2a(EUCOMM)Wtsi	FK506 binding protein 10; targeted mutation 2a, Wellcome Trust Sanger Institute
Fkbp10^tm2a(EUCOMM)Wtsi	FK506 binding protein 10; targeted mutation 2a, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Fkbp10^tm2a(EUCOMM)Wtsi/Fkbp10^tm2a(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N