Phenotype Image Detail

Image

Caption

Ndrg2^tm1Kmori/Ndrg2⁺ mice are susceptible to tumour formation. (g) A hepatocellular carcinoma section from a mutant mouse liver was subjected to H&E staining. The results indicated the presence of a large sheet of hepatic cords composed of several hepatocytes of variable nuclei and cell sizes; the nuclei of the carcinoma cells were hyperchromatic with prominent nucleoli (scale bar, 22 um). (h) A bronchoalveolar carcinoma section from a mutant mouse lung was subjected to H&E staining. The histopathology demonstrated a well-circumscribed mass of a solid sheet of neoplastic cells containing hyperchromatic nuclei with signs of frequent mitosis and an indistinct basophilic cytoplasm (scale bar, 22 um). (i-k) Lymphoma sections from the mesenteric lymph node of a mutant mouse. The histopathology indicated the presence of diffuse pleomorphic large lymphoid cells with vesicular nuclei, prominent nucleoli and scant cytoplasm (i). Robust staining for CD3 was present in the cytoplasm (j), but B220 staining was negative (k) (scale bar, 22 um). (l-n) Lymphoma sections from a mutant mouse spleen were examined by histopathology. The results demonstrated pleomorphic large lymphoid cells with vesicular nuclei, prominent nucleoli, some nuclear distortion and numerous cells undergoing mitosis (l). Staining for CD3 revealed robust cytoplasmic staining in cells, ranging from white pulp to red pulp (m). B220 staining was negative (n) (scale bar, 22 um).

Copyright

This image is from Nakahata S, Nat Commun 2014;5():3393, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:210264

Associated Alleles

Symbol	Name
Ndrg2^tm1Kmori	N-myc downstream regulated gene 2; targeted mutation 1, Kazuhiro Morishita

Associated Genotypes

Allelic Composition	Genetic Background
Ndrg2^tm1Kmori/Ndrg2^+	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj