Phenotype Image Detail

Image

Caption

Spermatogenesis is disrupted in Setx^tm1.1Mfl/Setx^tm1.1Mfl (-/-) mice. A. Testes from 35-day-old wild-type (+/+) and mutant mice. B-C. Hematoxylin and eosin (H&E)-stained sections of testes from adults. Scale bar, 100 um. D-E. Enlarged images of regions in (B) and (C). Asterisks in (C) and (E) show vacuolated seminiferous tubules in which both spermatozoa and spermatids are absent. Scale bar, 100 um. F-G. H&E sections of epididymis from wild-type and mutant adult mice. While there are numerous spermatozoids (Spm) in wild-type epididymis, no sperm is present in mutant. Scale bar, 100 um. H. TUNEL stained sections of testes from adult WT and mutant mice. Many TUNEL-positive cells are observed in mutant testes. Scale bar, 50 um. (1) and (2) are magnifications of a seminiferous tubule.

Copyright

This image is from Becherel OJ, PLoS Genet 2013 Apr;9(4):e1003435, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:223053

Associated Alleles

Symbol	Name
Setx^tm1.1Mfl	senataxin; targeted mutation 1.1, Martin F Lavin

Associated Genotypes

Allelic Composition	Genetic Background
Setx^tm1.1Mfl/Setx^tm1.1Mfl	Not Specified