Phenotype Image Detail

Image

Caption

Accumulation of R-loops correlates with apoptosis in Setx^tm1.1Mfl/Setx^tm1.1Mfl (-/-) mice. A. R-loop and TUNEL co-staining of histological cross-sections of adult mutant mice revealed apoptosis in germ cells containing R-loops. Hoechst 33342 was used to stain for DNA. Scale bar, 50 um. B. Pre-treatment of consecutive testes sections from the same animal with RNAse H dramatically reduced R-loop signal intensity in mutants. Similar results were obtained for consecutive sections from different mutant animals (data not shown).

Copyright

This image is from Becherel OJ, PLoS Genet 2013 Apr;9(4):e1003435, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:223053

Associated Alleles

Symbol	Name
Setx^tm1.1Mfl	senataxin; targeted mutation 1.1, Martin F Lavin

Associated Genotypes

Allelic Composition	Genetic Background
Setx^tm1.1Mfl/Setx^tm1.1Mfl	Not Specified