Phenotype Image Detail

Image

Caption

Gng5^tm1.1Rbs/Gng5^tm1.1Rbs (Gng5-/-) mutants have decreased cell proliferation and survival. Sagittal cryosections of E9.5 control (Gng5+/+) and mutant embryos after immunohistochemical staining for DNA (DAPI, blue), cells in mitosis (anti-pHH3, green), and cells undergoing apoptosis (TUNEL, red). In all panels, rostral is at right, ventral at top. Panels A, D represent 10X views of control (A) and mutant (D) embryos, while Panels B,C,E,F show 20x views of control (B,C) and mutant (E,F) sections. The red arrowheads in C and F denote second heart field pharyngeal mesoderm and adjacent endoderm. The pharyngeal arches are numbered. H, heart; T, telencephalon; HB, hindbrain; O, otocyst; OFT, outflow tract; IFT; inflow tract; HT, heart tube (mutant only).

Copyright

This image is from Moon AM, PLoS One 2014;9(3):e90970, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:215128

Associated Alleles

Symbol	Name
Gng5^tm1.1Rbs	G protein subunit gamma 5; targeted mutation 1.1, Janet D Robishaw

Associated Genotypes

Allelic Composition	Genetic Background
Gng5^tm1.1Rbs/Gng5^tm1.1Rbs	B6J.Cg-Gng5^tm1.1Rbs