Phenotype Image Detail

Image

Caption

Histological features of anal squamous cell carcinoma (ASCC) in Tgfbr1^tm1.1Karl/Tgfbr1^tm1.1Karl Pten^tm1Hwu/Pten^tm1Hwu Tg(KRT14-cre/ERT)20Efu/0 mice. Representative saggital sections of ASCC tumors showing differentiated epithelial cells that grew as solid sheets or nests. Invasion of ASCC into surrounding tissue (B) and origination of ASCC (C). Coronal section of ASCC showing ASCC tumor in squamous epithelial (D) but not in columnar epithelial cells (E, F). (Hematoxylin and eosin staining).

This image is from Sun ZJ, PLoS One 2013;8(10):e74888, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:209026

Associated
Alleles

Symbol	Name
Pten^tm1Hwu	phosphatase and tensin homolog; targeted mutation 1, Hong Wu
Tgfbr1^tm1.1Karl	transforming growth factor, beta receptor I; targeted mutation 1.1, Stefan Karlsson

Associated
Genotypes

Allelic Composition	Genetic Background
Pten^tm1Hwu/Pten^tm1Hwu Tgfbr1^tm1.1Karl/Tgfbr1^tm1.1Karl Tg(KRT14-cre/ERT)20Efu/0	involves: 129 * 129S4/SvJae * C57BL/6 * CD-1 * FVB/N

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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