Phenotype Image Detail

Image

Caption

Peripheral, but not central innervation is drastically reduced in Ntrk1^tm1.1Azmo/Ntrk1^tm1.1Azmo (TrkAC-KI) mice. (A-D) Peptidergic (CGRP-positive) and total (PGP9.5-positive) fiber innervation is decreased in thick glabrous skin of adult mutant hindlimbs. (E) Free nerve endings (FNE) counts in thick glabrous skin. Shown are means +/- s.e.m. from 8-10 sections from two animals per genotype (* p>0.05, ** p<0.01). (F-I) Peptidergic (CGRP-positive) and total (PGP9.5-positive) fiber innervation is decreased in thin glabrous skin of adult mutant hindlimbs. (J) FNE counts in thin glabrous skin. Shown are means +/- s.e.m. from 8-10 sections from two animals per genotype (* p>0.05, ** p<0.01). (K,L) Central projections are normal in mutant mice. Peptidergic (CGRP-positive, green) and nonpeptidergic (IB4-positive, red) fibers normally innervate adult spinal cord in mutant mice. Scale bar is 50 um.

Copyright

This image is from Gorokhova S, PLoS Genet 2014 Feb;10(2):e1004081, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:210892

Associated Alleles

Symbol	Name
Ntrk1^tm1.1Azmo	neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1.1, Aziz Moqrich

Associated Genotypes

Allelic Composition	Genetic Background
Ntrk1^tm1.1Azmo/Ntrk1^tm1.1Azmo	involves: 129S2/SvPas