Phenotype Image Detail

Image

Caption

Crx^tm1.1Smgc/Crx⁺ (E168d2/+) but not Crx^tm2.1Smgc/Crx⁺ (R90W/+) develop dominant retinopathy. A-P. Retinal morphology of the indicated heterozygous mutant mice was assessed by H&E staining of paraffin embedded sagittal sections at P14, 1 month, 3 months, and 6 months. Shortened photoreceptor outer segments and outer nuclear layer (ONL) cell loss are apparent in the Crx^tm1.1Smgc/Crx⁺ retina only.

Copyright

This image is from Tran NM, PLoS Genet 2014 Feb;10(2):e1004111, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:211011

Associated Alleles

Symbol	Name
Crx^tm1.1Smgc	cone-rod homeobox; targeted mutation 1.1, Shiming Chen
Crx^tm2.1Smgc	cone-rod homeobox; targeted mutation 2.1, Shiming Chen

Associated Genotypes

Allelic Composition	Genetic Background
Crx^tm1.1Smgc/Crx^+	B6.129X1(CBA)-Crx^tm1.1Smgc
Crx^tm2.1Smgc/Crx^+	B6.129X1(CBA)-Crx^tm2.1Smgc