Phenotype Image Detail

Image

Caption

The ultra structure of rod outer segment (OS) and nuclear morphology was assessed by transmission electron microscopy. Micrographs of rod OS proximal to the retinal pigment epithelium (RPE) from wild-type (WT) control (U), Crx^tm1.1Smgc/Crx⁺ (E168d2/+, V) and Crx^tm1Smgc/Crx⁺ (E168d2neo/+, W) mice. Crx^tm1.1Smgc/Crx⁺ OS's are highly disorganized showing 'wave-like' OS membrane stacks (asterisks), vesiculated membranes '+' and vertically oriented OS membranes (triangles). Crx^tm1Smgc/Crx⁺ OS's only show minor 'wave-like' patterns and vesiculated membranes.

Copyright

This image is from Tran NM, PLoS Genet 2014 Feb;10(2):e1004111, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:211011

Associated Alleles

Symbol	Name
Crx^tm1.1Smgc	cone-rod homeobox; targeted mutation 1.1, Shiming Chen
Crx^tm1Smgc	cone-rod homeobox; targeted mutation 1, Shiming Chen

Associated Genotypes

Allelic Composition	Genetic Background
Crx^tm1.1Smgc/Crx^+	B6.129X1(CBA)-Crx^tm1.1Smgc
Crx^tm1Smgc/Crx^+	involves: 129X1/SvJ