Phenotype Image Detail

Image

Caption

Crx^tm1.1Smgc/Crx⁺ (E168d2/+), Crx^tm1Smgc/Crx⁺ (E168d2neo/+) and Crx^tm2.1Smgc/Crx⁺ (R90W/+) mice display abnormal cone nuclear localization in developing and adult retina. A-D. Sagittal retinal sections from the indicated mice at 1 month, stained for cone arrestin (CARR) (green) and nuclear marker DAPI (blue). To assess cone nuclear location, the outer nuclear layer (ONL) was arbitrarily divided into three zones, outer ONL (OONL), mid ONL (MONL) and inner ONL (IONL). A. WT cone nuclei were found only in the OONL, while Crx^tm1.1Smgc/Crx⁺ (E168d2/+), Crx^tm1Smgc/Crx⁺ (E168d2neo/+) and Crx^tm2.1Smgc/Crx⁺ (R90W/+) had varying numbers of cones localized to IONL or MONL (B&C white arrows). E, F. Cone nuclear position was quantified by counting the fraction of CARR+ nuclei in each ONL zone of sagittal retinal sections from P14 or 1 month mice of the indicated genotype (*p<0.05).

Copyright

This image is from Tran NM, PLoS Genet 2014 Feb;10(2):e1004111, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:211011

Associated Alleles

Symbol	Name
Crx^tm1.1Smgc	cone-rod homeobox; targeted mutation 1.1, Shiming Chen
Crx^tm1Smgc	cone-rod homeobox; targeted mutation 1, Shiming Chen
Crx^tm2.1Smgc	cone-rod homeobox; targeted mutation 2.1, Shiming Chen

Associated Genotypes

Allelic Composition	Genetic Background
Crx^tm1.1Smgc/Crx^+	B6.129X1(CBA)-Crx^tm1.1Smgc
Crx^tm1Smgc/Crx^+	involves: 129X1/SvJ
Crx^tm2.1Smgc/Crx^+	B6.129X1(CBA)-Crx^tm2.1Smgc