Phenotype Image Detail

Image

Caption

Piezo1^{Gt(RST343)Byg}/Piezo1^{Gt(RST343)Byg} (Piezo1^gt/gt) embryos display vascular remodeling defects. Representative images of PECAM1-stained E8.5 wild-type (Piezo1^+/+) and mutant whole-mount yolk sacs. (B) Quantification of PECAM1+ area in E8.5 wild-type and mutant whole-mount yolk sac from n = 3 experiments. (C) Representative H&E staining of E9.5 yolk sac cross-sections from wild-type and mutant embryos. (D) Quantification of vessel thickness from H&E staining of E9.5 yolk sac from n = 2 experiments. *P < 0.05, unpaired two-tailed Student t test. [Scale bars: 100 um (A) and 200 um (C).]

Copyright

This image is from Ranade SS, Proc Natl Acad Sci U S A 2014 Jul 15;111(28):10347-52. Copyright 2014 National Academy of Sciences, U.S.A. J:212179

Associated Alleles

Symbol	Name
Piezo1^Gt(RST343)Byg	piezo-type mechanosensitive ion channel component 1; gene trap RST343, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Piezo1^Gt(RST343)Byg/Piezo1^Gt(RST343)Byg	involves: 129P2/OlaHsd * C57BL/6J