Phenotype Image Detail

Image

Caption

Reduced adiposity and unilocular lipid droplets in Fitm2^tm1.1Dls/Fitm2^tm1.1Dls Tg(Fabp4-cre)1Rev/? Lep^ob/Lep^ob mice. Histological sections of epididmyal white adipose tissue (EWAT) (D) and histological sections of brown adipose tissue (BAT) from Fitm2^tm1.1Dls/Fitm2^tm1.1Dls Lep^ob/Lep^ob (LL/obob) and Fitm2^tm1.1Dls/Fitm2^tm1.1Dls Tg(Fabp4-cre)1Rev/? Lep^ob/Lep^ob (AF2KO/obob) mice stained with H&E or immunolocalization of F4/80. The sections shown for H&E and F4/80 are non-consecutive. E, histological sections of BAT from LL/obob and AF2KO/obob mice stained with H&E show the appearance of larger unilocular lipid droplets (LDs) in AF2KO BAT than in LL/obob BAT. Data are represented as mean +/- S.D. (error bars) (n = 5-8 mice/genotype). ***, p <0.0001; ns, not significant.

Copyright

This image is from Miranda DA, J Biol Chem 2014 Apr 4;289(14):9560-72 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:212437

Associated Alleles

Symbol	Name
Fitm2^tm1.1Dls	fat storage-inducing transmembrane protein 2; targeted mutation 1.1, David L Silver
Lep^ob	leptin; obese

Associated Genotypes

Allelic Composition	Genetic Background
Fitm2^tm1.1Dls/Fitm2^tm1.1Dls Lep^ob/Lep^ob Tg(Fabp4-cre)1Rev/?	involves: 129S6/SvEvTac * C57BL/6J