Phenotype Image Detail

Image

Caption

Representative microphotographs of different sites of the brain and spinal cord of L2hgdh^{Gt(DC0625)Wtsi}/L2hgdh^{Gt(DC0625)Wtsi} (L2hgdh-/-) compared to wild-type (WT) mice. A-D, transverse sections through the corpus callosum (cc); E-H, transverse sections through the hippocampus (dg, dentate gyrus); I-L, sections through the cerebellum and cerebellar nuclei (cn); M-P, transverse sections through the spinal cord (ah, anterior horn). Left panels (A, B, E, F, I, J, M, N) are representative of WT mice and right panels (C, D, G, H, K, L, O, P) of mutant mice. On each side, the right panel is a higher magnification of the left panel, where arrows indicate lesions seen in brains of mutant mice. Scale bars correspond to 300 um or 50 um as indicated.

Copyright

This image is from Rzem R, PLoS One 2015;10(3):e0119540, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:228407

Associated Alleles

Symbol	Name
L2hgdh^Gt(DC0625)Wtsi	L-2-hydroxyglutarate dehydrogenase; gene trap DC0625, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
L2hgdh^Gt(DC0625)Wtsi/L2hgdh^Gt(DC0625)Wtsi	involves: 129P2/OlaHsd * C57BL/6