Phenotype Image Detail

Image

Caption

The number of fast muscle fibers decreased while the number of slow fibers increased in the soleus of aged Gas7^tm1Slch/Gas7^tm1Slch (MT) mice compared to wild-type (WT). (A) and (B) show sequential cross-sections of 12 months old WT soleus; (E) and (F) show that of the mutant soleus. Muscle fiber subtypes (slow fibers, dot; fast fibers, asterisk) were identified by staining with MHC I and MHC II antibodies (scale bar, 200 um). Panels (C), (D), (G), and (H) show boxed areas at higher magnification. (I) Number of fibers comprising soleus. (J) Relative proportion of fast and slow fibers. (K) Measurements of the cross-sectional area of fast and slow fibers. (n = 1500 fibers from 4 mice for each genotype).

Copyright

This image is from Huang BT, PLoS One 2012;7(5):e37702, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:227375

Associated Alleles

Symbol	Name
Gas7^tm1Slch	growth arrest specific 7; targeted mutation 1, Sue Lin-Chao

Associated Genotypes

Allelic Composition	Genetic Background
Gas7^tm1Slch/Gas7^tm1Slch	B6.129-Gas7^tm1Slch